Study of the Radiosensitizing Action of Lithium Ascorbate Under Neutron and Photon Irradiation of Tumor Cells

Introduction. Radioresistance of cancer cells is a serious problem in radiation therapy tumor diseases. Radiosensitizers make malignant more sensitive to and increase the effectiveness therapy; however, their widespread clinical use limited by significant side effects. The development study new radiosensitizers seems be an urgent task modern pharmacology. Aim. purpose this work was lithium ascorbate as radiosensitizer under influence photon neutron wide dose range. Materials methods. Evaluation biological effect carried out using line prostate PC-3. We used cyclotron produce Cobalt-60 source gamma radiation. Results discussion. have proved cytotoxic with combined different types ionizing ascorbate. resistance at absorbed 0.5–3.0 Gy revealed. It shown that are effects drug minimal concentrations combination irradiation compared same dose. main mechanism radiosensitizing action local induction oxidative stress, which synergistically enhances Conclusion. leads pronounced resulting effect. An concentration led pro-oxidative damaging on cells.